Women have faced systemic marginalization in the field of science as for centuries, societal norms and gender biases have limited women's access to education,  entry to prestigious scientific institutions, career opportunities, and recognition in the scientific community.  Despite barriers, pioneering scientists like physicist Marie Curie (1867-1934), chemist Rosalind Franklin (1920-1958), mathematician Ada Lovelace, and astrophysicist Andrea Ghez, just to name a few, have made significant contributions to their respective fields, but their work was often overlooked or attributed to male colleagues. It was not until the 20th century that women began to break through these barriers.  Despite the challenges that persist, and considerable progress in the 21st century in recognition and representation, to ensure that women's voices and contributions are valued and recognized, this course will cover a dozen or so of the most pioneering women of science and the importance of their discoveries and contributions to our world today.